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unknown site antagonist Guaifenesin – an expectorant Huperzine A – a naturally occurring acetylcholinesterase inhibitor and potential antidementia agent Ibogaine – a naturally occurring hallucinogen and antiaddictive agent Ketobemidone – an opioid analgesic Methadone – an opioid analgesic Minocycline – an antibiotic [100] Tramadol – an atypical opioid analgesic and serotonin releasing agent Negative allosteric modulators include: 25-Hydroxycholesterol – endogenous weak negative allosteric modulator Conantokins – naturally occurring negative allosteric modulators of the polyamine site found in Conus geographus [101] Modulators [edit] Examples [edit] The NMDA receptor is modulated by a number of endogenous and exogenous compounds: [102] Aminoglycosides have been shown to have a similar effect to polyamines, and this may explain their neurotoxic effect

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