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Instead, a subset — including D-isocitric acid, L-dehydro-ascorbate, uric acid, L-glutamate, pyrophosphate, oxaloacetic acid, ADP, oxoglutaric acid, citric acid, L-glutamic acid 5-phosphate, uridine, fructose 1,6-bisphosphate, cyclic AMP, xanthosine, and riboflavin — showed an opposite trajectory, persisting or increasing at later time points

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The quality of evidence was based on the GRADE approach (Grades of Recommendation, Assessment, Development and Evaluation), which describes four levels of quality: high, moderate, low and very low [21,22]