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Pb also induces receptor-specific dysfunction, including preferential inhibition of NMDA receptors, altered modulation of AMPA receptors by Zn²⁺, and downregulation of mGluRs, further compromising neural plasticity
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In contrast, the combination of the TrxR inhibitor Auranofin with COJEC had an additive effect that involved ferritinophagy-mediated lysosome accumulation and iron overload, reversing the COJEC-induced MES phenotype
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