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4.7.3 SCFAs may alleviate GERD symptoms by supporting immune homeostasis and reducing inflammation SCFA, especially butyrate, can alter the secretion of pro-inflammatory mediators (e.g., interferon (IFN) - γ (IL-1, IL-2, IL-6, IL-8, tumor necrosis factor (TNF) - α) by a possible mechanism through inhibition of NF-κB in intestinal epithelial cells (96, 97)
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