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specifically, fecal microbiota transplantation (FMT) experiments were conducted, including transferring dysbiotic fecal samples from patients with hypertension to germ-free mice (171) or feces from hypertensive stroke-prone SHRs to normotensive WKY rats, resulting in increased blood pressure in the recipients (173)
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However, the net effect of TGR5 activation within the TIME is complex and highly context-dependent
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