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At present, NNMT and CYP2E1 are the only two enzymes that act as NAM clearance enzymes [7], and both of them are classified into ADME genes which are involved in drug Absorption, Distribution, Metabolism, and Excretion by the PharmaADME Consortium ( [104]
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For healthy UK adults, the Reference Nutrient Intake is 1.5 micrograms daily, easily obtained through diet
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