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Interestingly, two patients reported a silent mutation in the GLRX5 gene, that results in non-syndromic microcytic congenital sideroblastic anaemia (cSA) [115,117] a condition that is associated with iron overload in mitochondria together with relative iron depletion in cytosol
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22 It is encoded by the genes ADH1A , ADH1B , and ADH1C , and genetic polymorphisms in ADH1B and ADH1C loci affect ethanol metabolism rate
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