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Subcutaneous Injection Sites Abdomen 2+ inches from navel, rotating around stomach area Outer Thighs Mid to upper outer thigh regions Upper Arms Back of upper arm (harder to self-inject) Upper Outer Quadrant of Buttocks Upper outer region for easy self-administration Proper Injection Technique Technique involves: Clean injection site with alcohol swab Pinch skin to create fold Insert needle at 45-90° angle into subcutaneous tissue Inject slowly and steadily Remove needle and apply gentle pressure without rubbing Critically: Rotate injection sites to never use the same spot consecutively Important Injection Considerations GHK-Cu specifically can cause injection site reactions ranging from mild to moderate pain due to copper peptide irritation, with possible redness, swelling, or knot formation lasting several days

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109 Since IDH inhibitors induce differentiation of leukemic blasts, this seems mechanistically plausible