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Among them, olefine bonds from α,β-unsaturated α-amino acids conserve the planarity of the peptide bond but no H-bonding because of the deletion of an oxygen atom, an acceptor

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A clinical trial examined the effectiveness and safety of administering a high dosage of folate (5000 mg/d) in combination with vitamins B6 and B12 in the treatment of mild to moderate Alzheimer’s disease, and their findings indicated that the treatment did not have a positive effect in slowing cognitive decline in the affected individuals and revealed an increased incidence of adverse events, including depression, in the participants [131]