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Therefore, although children with various genetic conditions and neurodevelopmental disorders usually have normal GH secretion as assessed by the classical criteria for diagnosing GH deficiency (155), altered IGF-1 levels or actions in the various compartments of the central nervous system of these patients can significantly influence brain development and function

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Herpes simplex virus 1 UL2 inhibits the TNF-α–Mediated NF-κB activity by interacting with p65/p50