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At the same time, the nanoparticle ppp-dsRNA that delivers Bcl-2-specific short interfering double-stranded RNA (dsRNA) through lipid calcium phosphate nanoparticles can also strongly induce the level of pro-inflammatory Th1 cytokines, increase the proportion of M1 TAMs and CD8 + T cells and reduce the levels of immunosuppressive B-regulating cells and plasma cells in TME thereby significantly inhibiting tumor growth (219)
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