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Observed molecular responses are dependent on experimental design, concentration, and model system, and are used to investigate peptide-mediated signalling rather than defined biological or clinical outcomes
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Metabolic approaches: GLP-1 Incretins (semaglutide): appetite suppression | GLP-1/GIP incretins (tirzepatide): dual hormonal agonism | 5-Amino-1MQ: NNMT enzyme inhibition — a non-hormonal mechanism, directly targeting lipid and NAD+ metabolism
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