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PI3Kgamma deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine

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It is possible that the increase in neuronal oscillations in the GluN2C KO following MK-801 administration is due to the increased inhibitory tone in the GluN2C KO and the consequently greater disinhibition of excitatory neurons and increase in oscillations following the blockade of the remaining populations of NMDARs in interneurons of either cortex or thalamus